Department of Psychiatry, Athens University Medical School, Eginition Hospital, Athens, Greece.
World J Biol Psychiatry. 2009;10(4 Pt 3):939-41. doi: 10.1080/15622970701463267.
Escitalopram (ESC) is the S-isomer of the racemic compound citalopram, and has been shown to be an efficacious treatment for major depressive disorder. Several studies or case reports are available describing its side effects, none of which however refer to its potential to induce ankle oedema. We report the case of a 69-year-old female depressed patient who, after approximately 1 month of therapy with ESC, progressively titrated up to 30 mg/day, developed a bilateral ankle oedema, which resolved completely within the first week following its discontinuation.
依西酞普兰（ESC）是消旋西酞普兰的 S-对映异构体，已被证明对治疗重度抑郁症有效。有几项研究或病例报告描述了其副作用，但均未提及 ESC 有引发踝部水肿的可能性。我们报告了一例 69 岁女性抑郁症患者的病例，该患者在 ESC 治疗约 1 个月后逐渐增加剂量至 30mg/天，出现双侧踝部水肿，停药后第一周内完全消退。
