Vigo Daniel E, Castro Mariana N, Dörpinghaus Andrea, Weidema Hylke, Cardinali Daniel P, Siri Leonardo Nicola, Rovira Bernardo, Fahrer Rodolfo D, Nogués Martín, Leiguarda Ramón C, Guinjoan Salvador M
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina.
World J Biol Psychiatry. 2008;9(3):183-9. doi: 10.1080/15622970701261604.
Patients with anorexia nervosa or bulimia nervosa often have signs of autonomic dysfunction potentially deleterious to the heart. The aim of this study was to ascertain the nonlinear properties of heart rate variability in patients with eating disorders. A group of 33 women with eating disorders (14 anorexia, 19 bulimia) and 19 healthy controls were included in the study. Conventional time- and frequency-domain heart rate variability measurements, along with nonlinear heart rate variability measurements including the short-term fractal scaling exponent alpha and approximate entropy (ApEn) were calculated. Anorexia nervosa patients exhibited decreased values of alpha, while bulimia nervosa patients had decreased values of ApEn. Low-frequency heart rate variability was decreased in patients with anorexia. In conclusion, these results are compatible with the view that a more severe alteration of cardiac autonomic function is present in anorexia than in bulimia.
神经性厌食症或神经性贪食症患者常常有自主神经功能障碍的迹象，这可能对心脏有害。本研究的目的是确定饮食失调患者心率变异性的非线性特性。该研究纳入了一组33名饮食失调女性（14名神经性厌食症患者，19名神经性贪食症患者）和19名健康对照者。计算了传统的时域和频域心率变异性测量值，以及包括短期分形标度指数α和近似熵（ApEn）在内的非线性心率变异性测量值。神经性厌食症患者的α值降低，而神经性贪食症患者的ApEn值降低。神经性厌食症患者的低频心率变异性降低。总之，这些结果与以下观点相符，即与神经性贪食症相比，神经性厌食症患者存在更严重的心脏自主神经功能改变。
