转移因子与高剂量强力新诺明C联合治疗儿童慢性乙型肝炎（HBe Ag阳性）。

Combination therapy with transfer factor and high dose stronger neo-minophagen C in chronic hepatitis B in children (HBe Ag positive).

作者信息

Sumiyama K, Kobayashi M, Miyashiro E, Koike M

机构信息

Department of Pediatrics, Wakayama Medical College, Japan.

出版信息

Acta Paediatr Jpn. 1991 Jun;33(3):327-34. doi: 10.1111/j.1442-200x.1991.tb01562.x.

DOI:10.1111/j.1442-200x.1991.tb01562.x

PMID:1785328

Abstract

This study mainly describes the efficacy of the combination therapy with Transfer Factor (TF) and high dose Stronger Neo-Minophagen C (SNMC) for HBV carrier children with HBe Ag positive chronic hepatitis. There were 12 patients, 10 males and 2 females aged from 7 months to 14 years 8 months. Liver biopsy was done in 11 patients, and the histopathological findings of the liver were chronic active hepatitis (8 cases) and chronic inactive hepatitis (3 cases). In 6 of 8 patients, HBe-Ag became negative (75%) within 18 weeks (mean 8 weeks) after the initiation of the combination therapy with TF and SNMC (HBe-seronegative), and 4 of these 8 patients (50%) became anti-HBe positive within 29 weeks (mean 15 weeks) (HBe-seroconversion). These results suggest that combination therapy with TF and high dose SNMC may be beneficial in the treatment of chronic hepatitis B in children.

摘要

本研究主要描述了转移因子（TF）与高剂量强力新（SNMC）联合治疗HBe Ag阳性慢性乙型肝炎病毒携带者儿童的疗效。共有12例患者，10例男性，2例女性，年龄从7个月至14岁8个月。11例患者进行了肝活检，肝脏组织病理学结果为慢性活动性肝炎（8例）和慢性非活动性肝炎（3例）。在8例患者中的6例（75%），在开始TF与SNMC联合治疗后的18周内（平均8周）HBe-Ag转为阴性（HBe血清学阴性），这8例患者中的4例（50%）在29周内（平均15周）抗-HBe转为阳性（HBe血清学转换）。这些结果表明，TF与高剂量SNMC联合治疗可能对儿童慢性乙型肝炎的治疗有益。