甘草酸苷对巨细胞病毒感染相关肝功能不全儿童的影响。

Effect of glycyrrhizin in children with liver dysfunction associated with cytomegalovirus infection.

作者信息

Numazaki K, Umetsu M, Chiba S

机构信息

Department of Pediatrics, School of Medicine, Sapporo Medical University, Japan.

出版信息

Tohoku J Exp Med. 1994 Feb;172(2):147-53. doi: 10.1620/tjem.172.147.

DOI:10.1620/tjem.172.147

PMID:8073426

Abstract

Glycyrrhizin (GL) has an inhibitory effect on several viruses including human immunodeficiency virus type 1 (HIV-1) and varicella-zoster virus (VZV). In addition, some therapeutic and prophylactic effects on chronic active viral hepatitis have been claimed for GL. In this study, 0.2% GL dissolved in saline (2 mg/ml GL), supplemented with 2% glycine and 0.1% cysteine (Stronger Neo-Minophagen C, SNMC) was administered intravenously in a dose of 50 ml/day for a period of more than one week to three infants with cytomegalovirus (CMV) infection who exhibited abnormal liver function or hepatomegaly. Liver function had become normal at the end of the course of SNMC. These findings suggest that GL might have therapeutic effects on liver dysfunction associated with CMV infections.

摘要

甘草酸（GL）对包括1型人类免疫缺陷病毒（HIV-1）和水痘带状疱疹病毒（VZV）在内的多种病毒具有抑制作用。此外，有人声称GL对慢性活动性病毒性肝炎有一些治疗和预防作用。在本研究中，将溶解于生理盐水的0.2%GL（2mg/ml GL），补充2%甘氨酸和0.1%半胱氨酸（强力新美能C，SNMC），以50ml/天的剂量静脉注射给三名表现出肝功能异常或肝肿大的巨细胞病毒（CMV）感染婴儿，持续一周以上。在SNMC疗程结束时，肝功能已恢复正常。这些发现表明，GL可能对与CMV感染相关的肝功能障碍具有治疗作用。