Isermann B, Ritzel R, Zorn M, Schilling T, Nawroth P P
Department of Internal Medicine I (Endocrinology) and Clinical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany.
Exp Clin Endocrinol Diabetes. 2007 Sep;115(8):483-90. doi: 10.1055/s-2007-981452.
Testing of autoantibodies in individuals at risk of developing or being newly diagnosed with diabetes mellitus is currently of very limited clinical value. However, clinical studies evaluating new therapeutic options for the delay or treatment of type 1 diabetes mellitus require sensitive, specific, and reliable assays for autoimmune antibodies associated with diabetes mellitus. With immune modulatory treatment of pre-diabetes mellitus on the horizon the need of reliable assays is evident. In addition, determination of autoimmune antibodies in diabetes mellitus facilitates studies investigating the pathophysiology underlying this disease. Clinicians and researchers should be aware of the tests available, their limitations, their clinical relevance, and their indications. This review focuses on the current knowledge about antibody assays for diabetes associated autoimmunity, their clinical value, their role in diagnosing and predicting autoimmune associated diabetes mellitus, and research applications.
对有患糖尿病风险或新诊断为糖尿病的个体进行自身抗体检测，目前临床价值非常有限。然而，评估1型糖尿病延迟或治疗新疗法的临床研究需要针对与糖尿病相关的自身免疫抗体的灵敏、特异且可靠的检测方法。鉴于糖尿病前期的免疫调节治疗即将出现，可靠检测方法的需求显而易见。此外，测定糖尿病患者的自身免疫抗体有助于研究该疾病的病理生理学。临床医生和研究人员应了解现有检测方法、其局限性、临床相关性及其适应症。本综述聚焦于目前有关糖尿病相关自身免疫性抗体检测的知识、其临床价值、在诊断和预测自身免疫性相关糖尿病中的作用以及研究应用。
