Fei Dong-Qing, Zhang Zhan-Xin, Chen Jian-Jun, Gao Kun
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Planta Med. 2007 Oct;73(12):1292-7. doi: 10.1055/s-2007-990217. Epub 2007 Sep 13.
Three new highly oxygenated eremophilane-type sesquiterpenes, 1 beta,10 beta(8,12)-diepoxy-7 beta,11 beta-dihydroxy-8 beta,12 alpha-dimethoxyeremophilane (1), 1 beta,10 beta-epoxy-7 beta-hydroxy-8 alpha-methoxyeremophil-11 alphaH-12,8 beta-olide (2), and 6 beta-isobutyryloxy-8 alpha-hydroxy-1-oxoeremophil-7(11),9-dien-12,8 beta-olide (3), together with nine known compounds (4-12) were isolated from the roots and aerial parts of Senecio nemorensis L. (Compositae). Structures of compounds 1-3 were elucidated on the basis of spectroscopic evidence including IR, HR-ESI-MS, 1D and 2D NMR techniques and were unequivocally confirmed by single-crystal X-ray diffraction experiments. The antimicrobial activity of the isolated compounds 1-3 and 8-12 was tested against Staphylococcus aureus and Candida albicans.
从菊科植物林阴千里光（Senecio nemorensis L.）的根和地上部分分离得到了三种新的高度氧化的桉叶烷型倍半萜，即1β,10β(8,12)-二环氧-7β,11β-二羟基-8β,12α-二甲氧基桉叶烷（1）、1β,10β-环氧-7β-羟基-8α-甲氧基桉叶烷-11αH-12,8β-内酯（2）和6β-异丁酰氧基-8α-羟基-1-氧代桉叶烷-7(11),9-二烯-12,8β-内酯（3），以及九种已知化合物（4 - 12）。化合物1 - 3的结构通过包括红外光谱（IR）、高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振（NMR）技术在内的光谱证据得以阐明，并通过单晶X射线衍射实验得到明确证实。对分离得到的化合物1 - 3和8 - 12针对金黄色葡萄球菌和白色念珠菌进行了抗菌活性测试。
