显脉橐吾根中的没药烷倍半萜

Bisabolane sesquiterpenes from the roots of Ligularia cymbulifera.

作者信息

Liu Chun-Mei, Fei Dong-Qing, Wu Qiu-Hong, Gao Kun

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.

出版信息

J Nat Prod. 2006 Apr;69(4):695-9. doi: 10.1021/np0505061.

DOI:10.1021/np0505061

PMID:16643057

Abstract

Eight new highly oxygenated bisabolane sesquiterpenes (1-8), of which one contains a chlorine atom, were obtained in a phytochemical investigation of the roots of Ligularia cymbulifera, and their structures were elucidated by interpretation of spectroscopic data. Their relative configurations were clarified by a detailed analysis of (1)H NMR coupling constants and by NOE experiments. Compounds 1-8 were evaluated for antimicrobial activity against three bacterial cultures and a yeast culture.

摘要

在对岩白菜叶橐吾根部进行的植物化学研究中，获得了8个新的高氧化度没药烷倍半萜（1-8），其中一个含有氯原子，通过光谱数据解析阐明了它们的结构。通过对¹H NMR耦合常数的详细分析和NOE实验明确了它们的相对构型。对化合物1-8针对三种细菌培养物和一种酵母培养物进行了抗菌活性评估。