Zhang Zhan-Xin, Lin Chang-Jun, Li Ping-Lin, Jia Zhong-Jian
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Planta Med. 2007 Jun;73(6):585-90. doi: 10.1055/s-2007-967201. Epub 2007 May 22.
Six new eremophilane sesquiterpenes, including a novel nortrieremophilane carbon skeleton, were isolated from the roots of Ligularia virgaurea. Their structures were elucidated as 3 alpha,4 alpha-epoxy-6 alpha-(2'-methylacryloyl)oxy-8 alpha-methoxyeremophil-7(11)-en-8 beta,12-olide (1), 3 alpha,4 alpha-epoxy-6 alpha-(2'-methylacryloyl)oxy-8 alpha-ethoxyeremophil-7(11)-en-8 beta,12-olide (2), 1 beta,10 beta-epoxy-6 beta-(2'-methylacryloyl)oxy-8 beta-methoxyeremophil-7(11)-en-8 alpha,12-olide (3), 1 beta,10 beta-epoxy-6 beta-angeloyloxy-8 beta-methoxyeremophil-7(11)-en-8 alpha,12-olide (4), 6 beta-methoxyeremophil-7(11)-en-8 beta,12-olide (5), and 5 beta-angeloyloxy-3a,4,5,6,7,7a-hexahydro-3a beta-methyl-1 H-indene-2,4 beta-dioic acid methyl ester (6) by spectral methods, including IR, HR-ESI-MS, 1D and 2D NMR techniques. All of compounds were evaluated for their in vitro cytotoxic activities against human hepatoma (SMMC-7721), human promyelocytic leukemia (HL-60), and human hepatocyte (L-02) cells.
从黄帚橐吾的根部分离出6种新的艾里莫芬烷倍半萜，其中包括一种具有新型降艾里莫芬烷碳骨架的化合物。通过红外光谱（IR）、高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振技术等光谱方法，确定它们的结构分别为3α,4α-环氧-6α-(2'-甲基丙烯酰)氧基-8α-甲氧基艾里莫芬-7(11)-烯-8β,12-内酯（1）、3α,4α-环氧-6α-(2'-甲基丙烯酰)氧基-8α-乙氧基艾里莫芬-7(11)-烯-8β,12-内酯（2）、1β,10β-环氧-6β-(2'-甲基丙烯酰)氧基-8β-甲氧基艾里莫芬-7(11)-烯-8α,12-内酯（3）、1β,10β-环氧-6β-当归酰氧基-8β-甲氧基艾里莫芬-7(11)-烯-8α,12-内酯（4）、6β-甲氧基艾里莫芬-7(11)-烯-8β,12-内酯（5）以及5β-当归酰氧基-3a,4,5,6,7,7a-六氢-3aβ-甲基-1H-茚-2,4β-二甲酸甲酯（6）。对所有化合物进行了体外抗人肝癌细胞（SMMC-7721）、人早幼粒白血病细胞（HL-60）和人肝细胞（L-02）的细胞毒活性评价。
