Sasaki N, Miyamoto S, Niimi H, Nakajima H
Division of Endocrinology, Chiba Children's Hospital, Japan.
Acta Paediatr Jpn. 1991 Jun;33(3):375-80. doi: 10.1111/j.1442-200x.1991.tb01569.x.
The C-peptide/creatinine (Cr) ratio in early morning urine was evaluated to assess B-cell function. The subjects were 12 boys and 36 girls with insulin-dependent diabetes mellitus (IDDM). The controls were 130 boys and 137 girls aged 4-15 years. There was a significant inverse correlation of this ratio with the duration of insulin therapy (r = -0.5807, P less than 0.01). The daily insulin dose in U/kg was significantly different among the following groups: 1.22 +/- 0.31 U/kg in group 1 with undetectable C-peptide, 0.94 +/- 0.37 in group 2 with a decreased ratio and 0.45 +/- 0.28 in group 3 with a normal ratio. HbA1 levels were 11.3 +/- 1.6% in group 1 and 9.2 +/- 1.1% in group 3. The difference was significant. The result shows that the C-peptide/Cr ratio in early morning urine is useful for assessing B-cell function in diabetic children.
评估晨尿中C肽/肌酐（Cr）比值以评估B细胞功能。研究对象为12名患胰岛素依赖型糖尿病（IDDM）的男孩和36名患IDDM的女孩。对照组为130名4至15岁的男孩和137名4至15岁的女孩。该比值与胰岛素治疗时长呈显著负相关（r = -0.5807，P < 0.01）。以下几组每日胰岛素剂量（单位/千克）有显著差异：第1组C肽检测不到，为1.22±0.31单位/千克；第2组比值降低，为0.94±0.37单位/千克；第3组比值正常，为0.45±0.28单位/千克。第1组糖化血红蛋白（HbA1）水平为11.3±1.6%，第3组为9.2±1.1%。差异显著。结果表明，晨尿中C肽/Cr比值有助于评估糖尿病儿童的B细胞功能。
