Rappaport E B, Ulstrom R A, Etzwiler D D, Fife D, Hedlund B E, Steffes M W
Am J Dis Child. 1980 Dec;134(12):1129-33. doi: 10.1001/archpedi.1980.02130240013006.
Urinary C-peptide excretion was investigated as a method for monitoring beta-cell function in diabetic patients and for studying the contribution of endogenous insulin production to diabetic control. Control subjects had variations in serum and urine C-peptide immunoreactivity that correlated with basal and meal-related insulin secretion. In a group of well-controlled juvenile diabetic patients, those receiving high doses of insulin had low or negligible C-peptide excretion, whereas most patients with low exogenous insulin requirements had near-normal urinary C-peptide excretion. Patients treated for diabetic ketoacidosis had recovery of beta-cell function as measured by C-peptide immunoreactivity in serial urine specimens. Thus, measurement of urinary C-peptide excretion is a simple technique that may be useful in assessing endogenous insulin production in juvenile diabetic patients.
尿C肽排泄作为一种监测糖尿病患者β细胞功能以及研究内源性胰岛素产生对糖尿病控制作用的方法进行了研究。对照受试者血清和尿C肽免疫反应性存在变化，这些变化与基础及与进餐相关的胰岛素分泌相关。在一组血糖控制良好的青少年糖尿病患者中，接受高剂量胰岛素治疗的患者C肽排泄量低或可忽略不计，而大多数外源性胰岛素需求量低的患者尿C肽排泄接近正常。接受糖尿病酮症酸中毒治疗的患者，通过连续尿标本中的C肽免疫反应性测量显示β细胞功能有所恢复。因此，测量尿C肽排泄是一种简单的技术，可能有助于评估青少年糖尿病患者的内源性胰岛素产生情况。
