Sempels C, Sienaert P
Universitair Psychiatrisch Centrum-Katholieke Universiteit Leuven, campus Kortenberg, Belgie.
Tijdschr Psychiatr. 2007;49(9):639-47.
There is great interest in the use of omega-3 fatty acids in the treatment of various psychiatric disorders. Epidemiological investigations show that a high consumption of omega-3 fatty acids is in inverse proportion to the prevalence of affective disorders.
To provide an overview of current research reports on the use of omega-3 fatty acids and bipolar disorders.
Medline was searched with the following MeSH terms: 'mood disorders', 'affective disorders', 'bipolar disorders', 'fish oil', 'unsaturated dietary fats', 'omega-3 fatty acids', 'eicosapentaenoic acid', 'docosahexaenoic acid' and 'alpha-linolenic acid'. results To date, articles have been published about four randomized controlled trials and one open-label study. Omega-3 fatty acids, when added to an existing psychopharmacological maintenance treatment for bipolar disorder, can have a slight beneficial effect on depressive symptoms. There is no clear evidence that this combination has a beneficial effect on manic symptoms.
Current data on the efficacy of docosahexaenoic acid (dha) and eicosapentaenoic acid (epa) in the treatment of bipolar disorder are insufficient for us to draw definite conclusions that can guide clinical practice. Further investigations are required into the effects of omega-3 fatty acids on the various phases of bipolar disorder.
人们对使用ω-3脂肪酸治疗各种精神疾病有着浓厚兴趣。流行病学调查显示，ω-3脂肪酸的高摄入量与情感障碍的患病率成反比。
概述当前关于使用ω-3脂肪酸与双相情感障碍的研究报告。
使用以下医学主题词在Medline数据库中进行检索：“心境障碍”“情感障碍”“双相情感障碍”“鱼油”“不饱和膳食脂肪”“ω-3脂肪酸”“二十碳五烯酸”“二十二碳六烯酸”和“α-亚麻酸”。结果：迄今为止，已发表了约四项随机对照试验和一项开放标签研究。当将ω-3脂肪酸添加到现有的双相情感障碍心理药物维持治疗中时，对抑郁症状可能有轻微有益作用。没有明确证据表明这种联合治疗对躁狂症状有有益作用。
目前关于二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）治疗双相情感障碍疗效的数据不足，无法得出可指导临床实践的确切结论。需要进一步研究ω-3脂肪酸对双相情感障碍各阶段的影响。
