van Strater A C P, Bouvy P F
GGZ Duin- en Bollenstreek, Voorhout.
Tijdschr Psychiatr. 2007;49(2):85-94.
More and more interest is being shown in fish oil because it contains omega-3 fatty acids which may have beneficial effects in a wide range of somatic and psychiatric disorders.
To search the literature for evidence of the effectiveness of omega-3 fatty acids in affective disorders.
We studied the literature with the help of Pubmed (1966-March 2006) using the keywords 'depression', 'affective disorder', 'bipolar disorder', 'seasonal affective disorder', 'postpartum depression', 'puerperal depression', 'fatty acids', 'eicosapentaenoic acid', 'arachidonic acid', 'docosahexaenoic acid' and 'fish oil'. We obtained additional information from the bibliographic references attached to the articles concerned.
Epidemiological studies and studies on fatty acid concentrations suggest a link between omega-3 fatty acids and affective disorders, although some of the results are contradictory. Some clinical investigations found that treatment with omega-3 fatty acids did have a positive effect, but the number of test subjects was very limited and some investigations even produced negative results.
There is insufficient clinical evidence to prove conclusively that treatment with omega-3 fatty acids has a beneficial effect on affective disorders.
人们对鱼油的兴趣日益浓厚，因为它含有ω-3脂肪酸，可能对多种躯体和精神疾病具有有益作用。
检索文献，寻找ω-3脂肪酸治疗情感障碍有效性的证据。
我们借助PubMed（1966年至2006年3月），使用关键词“抑郁症”“情感障碍”“双相情感障碍”“季节性情感障碍”“产后抑郁症”“产褥期抑郁症”“脂肪酸”“二十碳五烯酸”“花生四烯酸”“二十二碳六烯酸”和“鱼油”对文献进行研究。我们从相关文章所附的参考文献中获取了更多信息。
流行病学研究和脂肪酸浓度研究表明ω-3脂肪酸与情感障碍之间存在联系，尽管部分结果相互矛盾。一些临床研究发现，ω-3脂肪酸治疗确实有积极效果，但受试对象数量非常有限，且一些研究甚至得出了负面结果。
尚无充分的临床证据能确凿证明ω-3脂肪酸治疗对情感障碍有有益作用。
