Nagura H, Ohtani H, Masuda T, Kimura M, Nakamura S
Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.
Acta Pathol Jpn. 1991 Nov;41(11):818-23. doi: 10.1111/j.1440-1827.1991.tb01624.x.
The expression of major histocompatibility complex (MHC) class II (HLA-DR) antigens on M cells within follicle-associated epithelial cells (FAE) covering Peyer's patches was analyzed immunohistochemically. HLA-DR antigens were strongly expressed on M cells and cells with dendritic morphology, whereas other FAE covering Peyer's patches showed weak, but definite staining. Dendritic cells were also positive for S-100 protein and IL-1. These findings suggest that M cells as well as dendritic cells within FAE form an antigen-presenting cell system and contribute to the first information releaser for the mucosal immune system.
采用免疫组织化学方法分析了覆盖派尔集合淋巴结的滤泡相关上皮细胞（FAE）内M细胞上主要组织相容性复合体（MHC）Ⅱ类（HLA - DR）抗原的表达情况。HLA - DR抗原在M细胞和具有树突状形态的细胞上强烈表达，而覆盖派尔集合淋巴结的其他FAE显示出较弱但明确的染色。树突状细胞对S - 100蛋白和白细胞介素 - 1也呈阳性。这些发现表明，FAE内的M细胞以及树突状细胞形成了一个抗原呈递细胞系统，并有助于黏膜免疫系统的首个信息释放。
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