Department of Immunology, University of Medicine and Pharmacy, Iuliu Haţieganu Cluj-Napoca, Romania.
Clin Exp Immunol. 2012 Mar;167(3):405-12. doi: 10.1111/j.1365-2249.2011.04523.x.
Enterocytes used to be studied particularly in terms of digestion protagonists. However, as the immune functions of the intestinal tract were better understood, it became clear that enterocytes are not mere bystanders concerning the induction of immune tolerance to dietary peptides and gut microbiota. In fact, enterocytes are involved actively in shaping the intestinal immune environment, designed for maintaining a non-belligerent state. This tolerant milieu of the gut immune system is achieved by keeping a balance between suppression and stimulation of the inflammatory responses. Our review presents the current state of knowledge concerning the relationship between enterocytes and immune cells (dendritic cells, lymphocytes), with emphasis on the enterocytes' impact on the mechanisms leading to the induction of oral tolerance.
肠上皮细胞曾被特别研究为消化的主角。然而，随着对肠道免疫功能的更好理解，很明显，肠上皮细胞在诱导对膳食肽和肠道微生物群的免疫耐受方面不仅仅是旁观者。事实上，肠上皮细胞积极参与塑造肠道免疫环境，旨在维持非好斗状态。肠道免疫系统的这种耐受环境是通过在炎症反应的抑制和刺激之间保持平衡来实现的。我们的综述介绍了肠上皮细胞与免疫细胞（树突状细胞、淋巴细胞）之间关系的最新知识，重点介绍了肠上皮细胞对导致口服耐受的机制的影响。
