Chung Chi-Jen, Lin Hsin-I, Tsou Hsi-Kai, Shi Zhi-Yuan, He Ju-Liang
Department of Materials Science and Engineering, Feng Chia University, 100 Wen-Hua Rd., Taichung 40724, Taiwan, Republic of China.
J Biomed Mater Res B Appl Biomater. 2008 Apr;85(1):220-4. doi: 10.1002/jbm.b.30939.
Titanium dioxide (TiO2) has been developed and applied extensively in the form of coatings, in particular for its unique properties such as non-toxicity, high photocatalytic activity, and strong self-cleaning ability. These coatings, which can be prepared via various processes, have not yet been proved to be antimicrobial. This research involves an arc ion plating method to produce TiO2 film on medical grade AISI 304 stainless steel. Antimicrobial efficacy of the deposits is expected due to the photocatalysis action of the anatase phase presented in the deposit. The performance of the coating is evaluated by a JIS Z2801:2000 industrial standard. Experimental results show that TiO2 film mainly consisting of anatase structure can be prepared with a high growth rate of 5 microm/h. Antimicrobial activity (R) of the deposited TiO2 film against Staphylococcus aureus and Escherichia coli was 3.0 and 2.5, respectively, far beyond the value designated in JIS standard. This provides an effective antimicrobial surface coating method for medical implements thereby reducing the risk of hospital-acquired infections.
二氧化钛（TiO₂）已被开发并广泛应用于涂层形式，特别是因其具有诸如无毒、高光催化活性和强大的自清洁能力等独特性能。这些可以通过各种工艺制备的涂层，尚未被证明具有抗菌性。本研究涉及一种电弧离子镀方法，用于在医用级AISI 304不锈钢上制备TiO₂薄膜。由于沉积物中存在的锐钛矿相的光催化作用，预计沉积物具有抗菌效果。涂层性能通过JIS Z2801:2000工业标准进行评估。实验结果表明，可以制备出主要由锐钛矿结构组成的TiO₂薄膜，其生长速率高达5微米/小时。沉积的TiO₂薄膜对金黄色葡萄球菌和大肠杆菌的抗菌活性（R）分别为3.0和2.5，远远超过JIS标准中规定的值。这为医疗器具提供了一种有效的抗菌表面涂层方法，从而降低了医院获得性感染的风险。
