Singh A P, Peshin P K, Singh J, Sharifi D, Patil D B
Department of Veterinary Surgery and Radiology, College of Veterinary Science, Haryana Agricultural University, Hisar, India.
Acta Vet Hung. 1991;39(3-4):109-14.
Intramuscular (i.m.) and intravenous (i.v.) administration of detomidine at doses of 10, 20 and 40 micrograms/kg body mass was evaluated for its sedative and analgesic properties in 15 goats (Capra hircus). The drug produced dose- and route-dependent sedation. The 10 micrograms/kg dose was effective only when administered i.v. There was no observable analgesia at this dose. Higher doses produced effective sedation and moderate analgesia of the body with either route of administration. Severe ataxia and sternal recumbency were seen in all the animals after the dose of 40 micrograms/kg. Other effects of detomidine in these goats included mild to moderate salivation, depressed respiratory rate, decreased rectal temperature, bradycardia and hyperglycaemia. Plasma concentrations of total protein, sodium, potassium and chloride were not affected.
对15只山羊（Capra hircus）进行了研究，评估了按10、20和40微克/千克体重剂量肌肉注射（i.m.）和静脉注射（i.v.）右美托咪定的镇静和镇痛特性。该药物产生剂量和给药途径依赖性镇静作用。10微克/千克的剂量仅静脉注射时有效。此剂量下未观察到镇痛作用。更高剂量无论通过哪种给药途径都能产生有效的镇静作用和对身体的中度镇痛作用。40微克/千克剂量后，所有动物均出现严重共济失调和胸卧姿势。右美托咪定对这些山羊的其他影响包括轻度至中度流涎、呼吸频率降低、直肠温度下降、心动过缓和高血糖。血浆总蛋白、钠、钾和氯浓度未受影响。
