Peshin P K, Singh A P, Singh J, Patil D B, Sharifi D
Department of Veterinary Surgery and Radiology, College of Veterinary Sciences, Haryana Agricultural University, Hisar, India.
Acta Vet Hung. 1991;39(3-4):103-7.
Detomidine administered intramuscularly at a dose of 10, 20 or 40 micrograms/kg body mass was evaluated for its sedative effects in 15 unfasted infant calves (age: 15-20 days; body mass: 18-33 kg). The drug produced dose-dependent sedation. At a dose of 10 micrograms/kg detomidine produced effective sedation for 30 to 45 min without any observable analgesia. At doses of 20 or 40 micrograms/kg it caused deep sedation, sternal recumbency, and moderate analgesia of the trunk. Hyperglycaemia was recorded at all dose levels. The changes in respiratory rate, rectal temperature, haemoglobin, packed cell volume, total erythrocyte count and plasma concentration of total protein were not significant.
对15头未禁食的新生犊牛（年龄：15 - 20天；体重：18 - 33千克）评估了肌肉注射剂量为10、20或40微克/千克体重的地托咪定的镇静效果。该药物产生剂量依赖性镇静作用。剂量为10微克/千克时，地托咪定产生有效镇静作用30至45分钟，未观察到任何镇痛作用。剂量为20或40微克/千克时，它会引起深度镇静、胸卧姿势以及躯干中度镇痛。在所有剂量水平均记录到高血糖。呼吸频率、直肠温度、血红蛋白、红细胞压积、总红细胞计数和血浆总蛋白浓度的变化不显著。
