黏液样炎性纤维母细胞肉瘤，显示t(2;6)(q31;p21.3)为唯一的细胞遗传学异常。

Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality.

作者信息

Ida Cristiane M, Rolig Kristen A, Hulshizer Rachael L, Van Dyke Daniel L, Randolph Jamie L, Jenkins Robert B, Nascimento Antonio G, Oliveira Andre M

机构信息

Division of Anatomic Pathology, Hospital das Clinicas (C.M.I.), São Paulo University School of Medicine, São Paulo, SP, Brazil.

出版信息

Cancer Genet Cytogenet. 2007 Sep;177(2):139-42. doi: 10.1016/j.cancergencyto.2007.05.018.

DOI:10.1016/j.cancergencyto.2007.05.018

PMID:17854670

Abstract

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade sarcoma characterized by distinctive, large, and bizarre Reed--Sternberg--like cells associated with an intense inflammatory infiltrate. The biology of MIFS is still poorly understood, and only two previous cases had been studied cytogenetically. In the present case, analysis of MIFS in the foot of a 53-year-old man revealed the chromosome translocation t(2;6)(q31;p21.3) as the only cytogenetic abnormality. This finding is distinct from the two cases previously reported. Additional studies are needed to verify whether any of these chromosome rearrangements are involved recurrently in MIFS.

摘要

黏液炎性纤维母细胞肉瘤（MIFS）是一种罕见的低级别肉瘤，其特征为具有独特的、大的、怪异的里德-斯腾伯格样细胞，并伴有强烈的炎症浸润。MIFS的生物学特性仍知之甚少，此前仅有两例进行过细胞遗传学研究。在本病例中，对一名53岁男性足部的MIFS分析显示，染色体易位t(2;6)(q31;p21.3)是唯一的细胞遗传学异常。这一发现与之前报道的两例不同。需要进一步研究以验证这些染色体重排是否在MIFS中反复出现。