伴有由3号染色体片段组成的复杂额外环状染色体的黏液性炎性成纤维细胞肉瘤。

Myxoinflammatory fibroblastic sarcoma with complex supernumerary ring chromosomes composed of chromosome 3 segments.

作者信息

Mansoor Atiya, Fidda Nisreen, Himoe Eleanor, Payne Misty, Lawce Helen, Magenis R Ellen

机构信息

Department of Pathology, Oregon Health and Sciences University, Portland, OR 97239, USA.

出版信息

Cancer Genet Cytogenet. 2004 Jul 1;152(1):61-5. doi: 10.1016/j.cancergencyto.2003.10.004.

DOI:10.1016/j.cancergencyto.2003.10.004

PMID:15193443

Abstract

Myxoinflammatory fibroblastic sarcoma is a rare, recently described, and distinctive low-grade tumor of soft tissue. To our knowledge, there is only one previous report on the cytogenetics of this tumor. That case showed complex structural abnormalities, including a reciprocal translocation between chromosomes 1 and 10 [t(1;10)(p22;q24)] with loss of chromosomes 3 and 13. We describe here a second case showing supernumerary ring chromosomes, and a derivative chromosome 13, with additional material on the short arm. We conclude that the presence of chromosomal abnormalities supports the neoplastic nature of this tumor and aids in its diagnosis. Furthermore, we also postulate that the finding of ring chromosomes, which have been identified in other low-grade soft-tissue tumors, may have important prognostic implications regarding the aggressiveness of this neoplasm.

摘要

黏液样炎性纤维母细胞肉瘤是一种罕见的、最近才被描述的、独特的软组织低度肿瘤。据我们所知，此前仅有一篇关于该肿瘤细胞遗传学的报道。该病例显示出复杂的结构异常，包括1号和10号染色体之间的相互易位[t(1;10)(p22;q24)]，以及3号和13号染色体缺失。我们在此描述第二例病例，该病例显示有额外的环状染色体以及一条衍生的13号染色体，其短臂上还有额外的物质。我们得出结论，染色体异常的存在支持了该肿瘤的肿瘤性质并有助于其诊断。此外，我们还推测，在其他低度软组织肿瘤中已被发现的环状染色体的发现，可能对该肿瘤的侵袭性具有重要的预后意义。