Department of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Am J Surg Pathol. 2010 Nov;34(11):1723-7. doi: 10.1097/PAS.0b013e3181f17d51.
Myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor are rare, slow-growing soft tissue tumors of the distal extremities with recurrent potential. Recent cytogenetic studies have shown a t(1;10)(p22;q24) or der(10)t(1;10) in combination with aberrations of chromosome 3 in a limited number of cases of both entities. Here we report a case of a 42-year-old female with a soft tissue tumor of the ankle showing hybrid morphologic features of myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor, a der(10)t(1;10), and abnormalities of chromosome 3. This hybrid lesion provides further evidence for a close relationship between these 2 tumor types.
黏液炎症性纤维母细胞肉瘤和含铁血黄素性纤维脂肪瘤样肿瘤是罕见的、生长缓慢的四肢远端软组织肿瘤，具有潜在的复发性。最近的细胞遗传学研究显示，在这两种实体肿瘤的少数病例中，存在 t(1;10)(p22;q24)或 der(10)t(1;10)，并伴有 3 号染色体的异常。在这里，我们报告了一例 42 岁女性的踝部软组织肿瘤，其具有黏液炎症性纤维母细胞肉瘤和含铁血黄素性纤维脂肪瘤样肿瘤的混合形态学特征、der(10)t(1;10)和 3 号染色体异常。这种混合病变进一步证明了这两种肿瘤类型之间的密切关系。
