Park Tae Sung, Song Jaewoo, Lee Kyung-A, Lee Sang-Guk, Min Yoo Hong, Choi Jong Rak
Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea.
Cancer Genet Cytogenet. 2007 Sep;177(2):158-60. doi: 10.1016/j.cancergencyto.2007.07.003.
A 56-year-old woman was brought to the emergency room with gum swelling and pain. Biopsy of the gingiva revealed sheet-like proliferation of myeloperoxidase and CD45-positive large cells, and she was diagnosed with granulocytic sarcoma. Two years later, bone marrow involvement of granulocytic sarcoma was suspected. Her chromosome study repeatedly revealed a 46,XX,t(5;12)(q13;p13) karyotype. Case reports of t(5;12)(q13;p13) are extremely rare in the literature. To our knowledge, this is the first report of t(5;12)(q13;p13) in a patient with acute myelogenous leukemia with preceding granulocytic sarcoma.
一名56岁女性因牙龈肿胀和疼痛被送往急诊室。牙龈活检显示髓过氧化物酶和CD45阳性大细胞呈片状增殖，她被诊断为粒细胞肉瘤。两年后，怀疑粒细胞肉瘤累及骨髓。她的染色体研究多次显示核型为46,XX,t(5;12)(q13;p13)。文献中关于t(5;12)(q13;p13)的病例报告极为罕见。据我们所知，这是首例急性髓系白血病合并先前粒细胞肉瘤患者出现t(5;12)(q13;p13)的报告。
