Crisponi Guido, Nurchi Valeria Marina, Pivetta Tiziana
Centro Interdipartimentale per lo Studio dei Metalli in Medicina, Dipartimento di Scienze Chimiche, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy.
J Inorg Biochem. 2008 Feb;102(2):209-15. doi: 10.1016/j.jinorgbio.2007.07.038. Epub 2007 Aug 10.
The coordination properties of mixed catechol-bisphosphonates towards Fe(III) are presented. From the potentiometric and spectroscopic results it was possible to state that iron coordination takes place only on the bisphosphonate moiety at acidic pH, and involves both catechol and bisphosphonate groups on two different iron(III) ions at higher pH values. Steric constracts keep both groups from chelating the same metal ion. Quantum mechanical calculations confirm this statement and allow to determine the minimum length of the linker for a stable conformation of complexes in which the same iron(III) ion is coordinated by both catechol and bisphosphonate.
本文介绍了混合儿茶酚 - 双膦酸盐对Fe(III)的配位性质。根据电位滴定和光谱学结果可以表明，在酸性pH值下，铁配位仅发生在双膦酸盐部分，而在较高pH值下，两个不同的铁(III)离子上的儿茶酚和双膦酸盐基团都参与配位。空间结构阻碍了这两个基团螯合同一个金属离子。量子力学计算证实了这一说法，并能够确定连接基的最小长度，以实现儿茶酚和双膦酸盐同时配位同一个铁(III)离子的配合物的稳定构象。
