Crisponi Guido, Nurchi Valeria Marina, Pivetta Tiziana, Gałezowska Joanna, Gumienna-Kontecka Elzbieta, Bailly Théodorine, Burgada Ramon, Kozłowski Henryk
Centro Interdipartimentale per lo Studio dei Metalli in Medicina, Dipartimento di Scienze Chimiche, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy.
J Inorg Biochem. 2008 Jul;102(7):1486-94. doi: 10.1016/j.jinorgbio.2008.01.010. Epub 2008 Jan 26.
Coordination properties toward Fe(III) and Al(III) of a mixed bisphosphonate-hydroxypyridinonate ligand are presented. Potentiometric, spectrophotometric and NMR results allowed to conclude that Fe(III) and Al(III) coordination takes place on the pyridinone moiety. The high steric hindrance prevents the possibility of simultaneous coordination of both groups to the same metal ion. Quantum mechanical calculations confirm this finding allowing to determine the minimal length of the linker necessary for a stable conformation of complexes in which Fe(III) is coordinated both by pyridinone and bisphosphonate groups.
本文介绍了一种双膦酸盐 - 羟基吡啶酮混合配体对Fe(III)和Al(III)的配位性质。电位滴定、分光光度法和核磁共振结果表明，Fe(III)和Al(III)的配位发生在吡啶酮部分。较大的空间位阻使得两个基团不可能同时与同一个金属离子配位。量子力学计算证实了这一发现，并确定了使Fe(III)同时与吡啶酮和双膦酸盐基团配位的配合物具有稳定构象所需的连接基的最小长度。
