Nicaretta Denise Hack, de Rosso Ana Lucia Zuma, Maliska Carmelindo, Costa Milton Melciades Barbosa
25(a) Enfermaria da Santa Casa de Misericórdia do Rio de Janeiro e Serviço de Neurologia do Hospital Universitário Antonio Pedro da Universidade Federal Fluminense (UFF), Brazil.
Parkinsonism Relat Disord. 2008;14(4):338-41. doi: 10.1016/j.parkreldis.2007.07.008. Epub 2007 Sep 12.
Since sialorrhea was initially described, it has been associated with Parkinson's disease (PD) but until now little is known about its pathophysiology. The authors studied parotid gland activity using scintigraphic analysis on 14 PD patients with sialorrhea and in eight healthy persons with matching ages. There was no difference between uptake and intra-glandular distribution by the parotid gland in the two groups but the parotid excretion speed in the PD patients was greater than that observed in healthy individuals. Our results reject the hypothesis of PD productive sialorrhea and point to retention sialorrhea due to the increase of saliva excretion velocity.
自从流涎症最初被描述以来，它就一直与帕金森病（PD）相关，但直到现在对其病理生理学仍知之甚少。作者对14名患有流涎症的帕金森病患者和8名年龄匹配的健康人进行了闪烁扫描分析，以研究腮腺活动。两组腮腺的摄取和腺体内分布没有差异，但帕金森病患者的腮腺排泄速度高于健康个体。我们的结果否定了帕金森病导致流涎症的假设，并指出流涎症是由于唾液排泄速度增加导致的潴留性流涎。
