帕金森病患者的[(11)C]-匹兹堡化合物B成像：初步结果。
[(11)C]-PIB imaging in patients with Parkinson's disease: preliminary results.
作者信息
Johansson A, Savitcheva I, Forsberg A, Engler H, Långström B, Nordberg A, Askmark H
机构信息
Department of Neurology, University Hospital, SE-751 85 Uppsala, Sweden.
出版信息
Parkinsonism Relat Disord. 2008;14(4):345-7. doi: 10.1016/j.parkreldis.2007.07.010. Epub 2007 Sep 14.
[(11)C]-PIB positron emission tomography ([(11)C]-PIB PET) is a sensitive marker of amyloid in Alzheimer's disease (AD), but its specificity has not been fully evaluated. Vascular amyloid-beta deposition is common in Parkinson's disease (PD) and alpha-synuclein, the major component of the Lewy bodies in PD, forms amyloid fibrils. We investigated five apparently cognitively normal PD patients with [(11)C]-PIB PET. The results were compared to 16 patients with AD and six healthy controls from a previous study. [(11)C]-PIB retention was not significantly increased in our patients who all had early stage PD. Further studies of more advanced PD patients are warranted.
[11C] - 匹兹堡复合物B正电子发射断层扫描（[11C] - PIB PET）是阿尔茨海默病（AD）中淀粉样蛋白的敏感标志物，但其特异性尚未得到充分评估。血管淀粉样β沉积在帕金森病（PD）中很常见，并且α - 突触核蛋白（PD中路易小体的主要成分）会形成淀粉样纤维。我们对5名表面认知正常的PD患者进行了[11C] - PIB PET检查。将结果与先前研究中的16名AD患者和6名健康对照进行了比较。在我们所有处于PD早期阶段的患者中，[11C] - PIB滞留并未显著增加。有必要对更晚期的PD患者进行进一步研究。
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