Fulghesu L, Giallorenzo C, Savoia D
Department of Clinical and Biological Sciences, University of Turin, Italy.
J Chemother. 2007 Aug;19(4):388-91. doi: 10.1179/joc.2007.19.4.388.
Quorum sensing (QS) controls systems affecting the pathogenicity of many microorganisms; its interruption has an anti-pathogenic effect and can be used in the treatment of bacterial infections. In this study we evaluated QS regulation by Pseudomonas aeruginosa strains and QS inhibition (QSI) by different compounds. The inhibitory activity of 3 macrolide and 3 lincosamide drugs, resveratrol, garlic extract and N-acetylcysteine was tested on 4 P. aeruginosa strains isolated from cystic fibrosis (CF) patients using Chromobacterium violaceum ATCC 12472 as biomonitor. One P. aeruginosa strain, lincomycin and N-acetylcysteine did not show QSI, contrary to other compounds and P. aeruginosa strains. These results indicate that QSI evaluation should be taken into account in the design of new therapeutic strategies to treat P. aeruginosa infections, especially in patients infected by antibiotic-resistant bacteria.
群体感应（QS）控制系统影响许多微生物的致病性；其阻断具有抗致病作用，可用于治疗细菌感染。在本研究中，我们评估了铜绿假单胞菌菌株的群体感应调控以及不同化合物的群体感应抑制（QSI）作用。使用紫色杆菌ATCC 12472作为生物监测器，测试了3种大环内酯类药物、3种林可酰胺类药物、白藜芦醇、大蒜提取物和N-乙酰半胱氨酸对从囊性纤维化（CF）患者中分离出的4株铜绿假单胞菌菌株的抑制活性。与其他化合物和铜绿假单胞菌菌株不同，一株铜绿假单胞菌菌株、林可霉素和N-乙酰半胱氨酸未表现出群体感应抑制作用。这些结果表明，在设计治疗铜绿假单胞菌感染的新治疗策略时，应考虑群体感应抑制评估，尤其是对于感染了耐药菌的患者。
