Nargund G, Fauser B C J M, Macklon N S, Ombelet W, Nygren K, Frydman R
Department of Reproductive Medicine, St George's Hospital and Medical School, London, UK.
Hum Reprod. 2007 Nov;22(11):2801-4. doi: 10.1093/humrep/dem285. Epub 2007 Sep 12.
IVF is performed with oocytes collected in natural and stimulated cycles. Different approaches to ovarian stimulation have been employed worldwide. Following the introduction of GnRH antagonists and strategies to reduce multiple births such as single embryo transfer, there is a genuine scientific interest in the revival of natural cycle and mild approaches to ovarian stimulation in IVF. Recent evidence suggests that application of natural and mild IVF is patient-centred, aimed at reducing the cost of treatment, patient discomfort and multiple pregnancies. However, there seems to be no consistency in the terminology used for definitions and protocols for ovarian stimulation in IVF cycles. Following the recent International Society for Mild Approaches in Assisted Reproduction (ISMAAR) meeting and communication with interested international experts, this article has recommended revised definitions and terminology for natural cycle IVF and different protocols used in ovarian stimulation for IVF. It is proposed that these terms are adopted internationally in order to achieve a consistency in clinical practice, research publications and communication with patients.
体外受精是利用在自然周期和促排卵周期中采集的卵母细胞进行的。世界各地采用了不同的卵巢刺激方法。随着促性腺激素释放激素拮抗剂的引入以及诸如单胚胎移植等减少多胎妊娠的策略的出现，人们对自然周期复苏以及体外受精中温和的卵巢刺激方法产生了真正的科学兴趣。最近的证据表明，自然和温和体外受精的应用是以患者为中心的，旨在降低治疗成本、患者不适和多胎妊娠。然而，在体外受精周期中卵巢刺激的定义和方案所使用的术语似乎并不一致。继最近的国际辅助生殖温和方法协会（ISMAAR）会议以及与感兴趣的国际专家交流之后，本文推荐了自然周期体外受精的修订定义和术语，以及体外受精卵巢刺激中使用的不同方案。建议在国际上采用这些术语，以便在临床实践、研究出版物以及与患者的沟通中实现一致性。
