Department of Reproductive Medicine and Gynaecology, University Medical Center, Utrecht, The Netherlands.
Hum Reprod. 2010 Nov;25(11):2678-84. doi: 10.1093/humrep/deq247. Epub 2010 Sep 21.
Ovarian stimulation to achieve multiple follicle development has been an integral part of IVF treatment. In the context of improved laboratory performance, the need for a large number of oocytes as an integral part of a successful IVF programme may be questioned. The aim of the current debate is to summarize the studies performed during the last decade to develop the concept of mild stimulation aiming to obtain fewer than eight oocytes. Here we examine the balance between IVF success and patient discomfort, and complications and cost, and how these might improve by simpler ovarian stimulation protocols aimed at retrieving fewer oocytes. We intend to analyse why progress has been rather slow and why there is much resistance to mild stimulation. Finally, presumed useful directions for future research will be discussed.
卵巢刺激以实现多个卵泡发育一直是 IVF 治疗的一个组成部分。在实验室性能提高的背景下，作为 IVF 成功计划的一个组成部分，需要大量的卵子可能会受到质疑。目前这场辩论的目的是总结过去十年进行的研究，以开发出温和刺激的概念，旨在获得少于 8 个卵子。在这里，我们研究了 IVF 成功率与患者不适、并发症和成本之间的平衡，以及通过旨在获得较少卵子的更简单的卵巢刺激方案，这些方面如何得到改善。我们旨在分析为什么进展相当缓慢，以及为什么对温和刺激存在很大的阻力。最后，将讨论未来研究的有用方向。
