Struik S S, Tudor-Williams G, Taylor G P, Portsmouth S D, Foster C J, Walsh C, Hanley C, Walters S, Smith J H, Lyall H
St Mary's NHS Trust, London W2 1NY, UK.
Arch Dis Child. 2008 Jan;93(1):59-61. doi: 10.1136/adc.2007.115980. Epub 2007 Sep 12.
We reviewed the antenatal HIV testing history, clinical presentation and outcome of 25 infants diagnosed with HIV between 1 January 2001 and 31 December 2005 in a tertiary referral hospital in London. Of the 25 cases, 21 had received antenatal care in the UK. Twelve mothers had not had an antenatal HIV test, four had tested positive antenatally, while five had had a negative HIV test on antenatal booking, implying seroconversion in pregnancy. When mothers had not been diagnosed antenatally, infants presented with severe infections, which were fatal in six cases. The majority (65%) of the children have long-term neurological sequelae. HIV seroconversion is an important cause of infant HIV in the UK.
我们回顾了2001年1月1日至2005年12月31日期间在伦敦一家三级转诊医院确诊感染艾滋病毒的25名婴儿的产前艾滋病毒检测史、临床表现和预后情况。在这25例病例中，21例在英国接受了产前护理。12名母亲未进行产前艾滋病毒检测，4名母亲产前检测呈阳性，而5名母亲在产前登记时艾滋病毒检测呈阴性，这意味着在孕期发生了血清转化。当母亲在产前未被诊断出感染时，婴儿会出现严重感染，其中6例死亡。大多数（65%）儿童有长期神经后遗症。在英国，艾滋病毒血清转化是婴儿感染艾滋病毒的一个重要原因。
