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与卡波西肉瘤相关疱疹病毒病毒干扰素调节因子1相互作用的DNA序列的鉴定

Identification of the DNA sequence interacting with Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 1.

作者信息

Park Junsoo, Lee Myung-Shin, Yoo Seung-Min, Jeong Kwi Wan, Lee Daeyoup, Choe Joonho, Seo Taegun

机构信息

Korea Basic Science Institute, Gwangju, Korea.

出版信息

J Virol. 2007 Nov;81(22):12680-4. doi: 10.1128/JVI.00556-07. Epub 2007 Sep 12.

DOI:10.1128/JVI.00556-07
PMID:17855527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2169006/
Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma. The open reading frame (K9) of KSHV encodes viral interferon regulatory factor 1 (vIRF1), which functions as a repressor of interferon-mediated signal transduction. The amino-terminal region of vIRF1 displays significant homology to the DNA-binding domain of cellular interferon regulatory factors, supporting the theory that the protein interacts with specific DNA sequences. Here, we identify the consensus sequence of vIRF1-binding sites from a pool of random oligonucleotides. Moreover, our data show that vIRF1 interacts with the K3:viral dihydrofolate reductase:viral interleukin 6 promoter region in the KSHV genome.

摘要

卡波西肉瘤相关疱疹病毒（KSHV）是卡波西肉瘤的病原体。KSHV的开放阅读框（K9）编码病毒干扰素调节因子1（vIRF1），其作为干扰素介导的信号转导的抑制剂发挥作用。vIRF1的氨基末端区域与细胞干扰素调节因子的DNA结合结构域显示出显著的同源性，支持了该蛋白与特定DNA序列相互作用的理论。在此，我们从一组随机寡核苷酸中鉴定出vIRF1结合位点的共有序列。此外，我们的数据表明vIRF1与KSHV基因组中的K3：病毒二氢叶酸还原酶：病毒白细胞介素6启动子区域相互作用。

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本文引用的文献

1
Kaposi sarcoma herpesvirus-encoded interferon regulator factors.卡波西肉瘤疱疹病毒编码的干扰素调节因子。
Curr Top Microbiol Immunol. 2007;312:185-209. doi: 10.1007/978-3-540-34344-8_7.
2
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors.转录因子干扰素调节因子家族对I型干扰素基因的诱导作用。
Immunity. 2006 Sep;25(3):349-60. doi: 10.1016/j.immuni.2006.08.009.
3
Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.卡波西肉瘤相关疱疹病毒干扰素调节因子1对ATM/p53信号转导通路的抑制作用
J Virol. 2006 Mar;80(5):2257-66. doi: 10.1128/JVI.80.5.2257-2266.2006.
4
Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 1 inhibits transforming growth factor-beta signaling.卡波西肉瘤相关疱疹病毒的病毒干扰素调节因子1抑制转化生长因子-β信号传导。
Cancer Res. 2005 Mar 1;65(5):1738-47. doi: 10.1158/0008-5472.CAN-04-2374.
5
Characterization of monoclonal antibodies against GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death.针对GRIM-19的单克隆抗体的特性研究，GRIM-19是一种新型的干扰素-β和视黄酸激活的细胞死亡调节因子。
J Interferon Cytokine Res. 2002 Oct;22(10):1017-26. doi: 10.1089/107999002760624242.
6
Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death.卡波西肉瘤相关疱疹病毒的病毒干扰素调节因子1与一种细胞死亡调节因子GRIM19相互作用，并抑制干扰素/视黄酸诱导的细胞死亡。
J Virol. 2002 Sep;76(17):8797-807. doi: 10.1128/jvi.76.17.8797-8807.2002.
7
On the role of IRF in host defense.关于干扰素调节因子在宿主防御中的作用。
J Interferon Cytokine Res. 2002 Jan;22(1):59-71. doi: 10.1089/107999002753452665.
8
Inhibition of p53 tumor suppressor by viral interferon regulatory factor.病毒干扰素调节因子对p53肿瘤抑制因子的抑制作用
J Virol. 2001 Aug;75(16):7572-82. doi: 10.1128/JVI.75.16.7572-7582.2001.
9
Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus binds to p53 and represses p53-dependent transcription and apoptosis.卡波西肉瘤相关疱疹病毒的病毒干扰素调节因子1与p53结合，并抑制p53依赖的转录和凋亡。
J Virol. 2001 Jul;75(13):6193-8. doi: 10.1128/JVI.75.13.6193-6198.2001.
10
HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators.人疱疹病毒8型编码的病毒干扰素调节因子1通过阻断CBP/p300共激活因子的干扰素调节因子3募集来抑制干扰素抗病毒反应。
Oncogene. 2001 Feb 15;20(7):800-11. doi: 10.1038/sj.onc.1204163.