卡波西肉瘤疱疹病毒编码的干扰素调节因子。

Kaposi sarcoma herpesvirus-encoded interferon regulator factors.

作者信息

Offermann M K

机构信息

Winship Cancer Institute, 1365-B Clifton Rd NE, Atlanta, GA 30322, USA.

出版信息

Curr Top Microbiol Immunol. 2007;312:185-209. doi: 10.1007/978-3-540-34344-8_7.

DOI:10.1007/978-3-540-34344-8_7

PMID:17089798

Abstract

The Kaposi sarcoma herpesvirus (KSHV) encodes multiple proteins that disrupt host antiviral responses, including four viral proteins that have homology to the interferon regulatory factor (IRF) family of transcription factors. At least three of the KSHV vIRFs (vIRFs 1-3) alter responses to cellular IRFs and to interferons (IFNs), whereas functional changes resulting from the fourth vIRF (vIRF-4) have not been reported. The vIRFs also affect other important regulatory proteins in the cell, including responses to transforming growth factor beta (TGF-beta) and the tumor suppressor protein p53. This review examines the expression of the vIRFs during the life cycle of KSHV and the functional consequences of their expression.

摘要

卡波西肉瘤疱疹病毒（KSHV）编码多种破坏宿主抗病毒反应的蛋白质，其中包括四种与转录因子干扰素调节因子（IRF）家族具有同源性的病毒蛋白。卡波西肉瘤疱疹病毒的病毒干扰素调节因子（vIRF）中至少有三种（vIRF 1 - 3）会改变对细胞IRF和干扰素（IFN）的反应，而第四种vIRF（vIRF - 4）所导致的功能变化尚未见报道。vIRF还会影响细胞中的其他重要调节蛋白，包括对转化生长因子β（TGF - β）和肿瘤抑制蛋白p53的反应。本文综述了vIRF在KSHV生命周期中的表达及其表达所产生的功能后果。