Everett B, Cameron B, Li H, Vollmer-Conna U, Davenport T, Hickie I, Wakefield D, Vernon S, Reeves W C, Lloyd A R
Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
Genes Immun. 2007 Dec;8(8):699-702. doi: 10.1038/sj.gene.6364428. Epub 2007 Sep 13.
Coxiella burnetii is a macrophage-tropic, Gram-negative organism, which causes acute Q fever infection in humans. This zoonotic infection causes illness ranging from asymptomatic seroconversion to severe and protracted disease featuring hepatitis and pneumonia. Interactions between C. burnetii lipopolysaccharide (LPS) and host Toll-like receptors (TLR)-2 and -4 have been implicated in pathogen recognition, phagocytosis and signaling responses. Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (Arg677Trp and Arg753Gln) and TLR-4 (Asp299Gly) have been found to correlate with mycobacterial infections and Gram-negative sepsis respectively. Associations between the TLR-2 and -4 polymorphisms, illness characteristics and immune response parameters were examined in subjects with acute Q fever (n=85) and comparison subjects with viral infections (n=162). No correlation was demonstrated between these polymorphisms and susceptibility to Q fever, illness severity or illness course.
伯氏考克斯体是一种嗜巨噬细胞的革兰氏阴性菌，可引起人类急性Q热感染。这种人畜共患感染可导致从无症状血清转化到以肝炎和肺炎为特征的严重且迁延性疾病等一系列病症。伯氏考克斯体脂多糖（LPS）与宿主Toll样受体（TLR）-2和-4之间的相互作用与病原体识别、吞噬作用及信号传导反应有关。已发现TLR-2（Arg677Trp和Arg753Gln）和TLR-4（Asp299Gly）编码区的非保守单核苷酸多态性分别与分枝杆菌感染和革兰氏阴性菌败血症相关。在急性Q热患者（n = 85）和病毒感染对照受试者（n = 162）中，研究了TLR-2和-4多态性、疾病特征及免疫反应参数之间的关联。未证实这些多态性与Q热易感性、疾病严重程度或病程之间存在相关性。
