Toll样受体4基因A299G多态性与肺炎风险的关联：一项荟萃分析

Association between TLR4 A299G polymorphism and pneumonia risk: a meta-analysis.

作者信息

Cai Xingjun, Fu Yihui, Chen Qingyun

机构信息

Department of Respiratory, Hainan Provincial People's Hospital, Haikou, Hainan, China (mainland).

出版信息

Med Sci Monit. 2015 Feb 27;21:625-9. doi: 10.12659/MSM.892557.

BACKGROUND

Several genetic studies have evaluated the association between Toll-like receptor 4 (TLR4) A299G polymorphism and the risk of pneumonia. However, the results were not consistent. We thus did this meta-analysis.

MATERIAL AND METHODS

Relevant studies were systematically searched by using the NCBI, Medline, Web of Science, and Embase databases. Data were extracted independently by 2 investigators. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated.

RESULTS

Eight case-control studies with 658 patients and 1862 controls were included in this meta-analysis. TLR4 A299G polymorphism was significantly associated with pneumonia risk (OR=1.74; 95% CI 1.19-2.53; P=0.004). The result was significant in adults. In addition, TLR4 A299G polymorphism was also associated with community-acquired pneumonia (CAP) risk. Results from cumulative meta-analysis and sensitivity analysis suggested that the results are reliable and robust.

CONCLUSIONS

The results of this meta-analysis suggest that susceptibility to pneumonia was associated with TLR4 A299G polymorphism.

背景

多项基因研究评估了Toll样受体4（TLR4）A299G多态性与肺炎风险之间的关联。然而，结果并不一致。因此，我们进行了这项荟萃分析。

材料与方法

通过使用NCBI、Medline、科学网和Embase数据库系统检索相关研究。由2名研究人员独立提取数据。估计比值比（OR）和相应的95%置信区间（CI）。

结果

本荟萃分析纳入了8项病例对照研究，共658例患者和1862例对照。TLR4 A299G多态性与肺炎风险显著相关（OR=1.74；95%CI 1.19 - 2.53；P=0.004）。该结果在成年人中具有显著性。此外，TLR4 A299G多态性也与社区获得性肺炎（CAP）风险相关。累积荟萃分析和敏感性分析结果表明，这些结果是可靠且稳健的。