Nomura Y, Abe Y, Yamagata J, Takenaka K
Gan. 1976 Feb;67(1):101-4.
The estrogen-binding capacity of the regrowing tumors after endocrine ablation surgery was estimated in the rat and human breast cancer. All of 4 tumors that had not had the estrogen receptor before oophorectomy did not show the estrogen-binding capacity after the procedure, in the mammary cancer in the Sprague-Dawley rat induced by 7,12-dimethylbenz[a]anthracene, whereas all the 4 tumors that had the receptor before the procedure showed the binding capacity after oophorectomy. In 4 patients who had been subjected to the major endocrine ablation therapy because of metastatic breast cancer with effective response, the secondary metastatic deposits of cancer showed the estrogen-binding capacity long after the endocrine ablation. The fact that regrowing tumors after complete or partial regression of initial tumors by endocrine ablation retain the estrogen receptor seems to be contradictory to the classical concept of autonomy in recurrence of the breast cancer after hormonal manipulation.
在内分泌消融手术后，对大鼠和人类乳腺癌中再生长肿瘤的雌激素结合能力进行了评估。在由7,12-二甲基苯并[a]蒽诱导的斯普拉格-道利大鼠的乳腺癌中，4个在卵巢切除术前没有雌激素受体的肿瘤，在该手术后均未显示出雌激素结合能力，而4个在手术前有该受体的肿瘤在卵巢切除术后显示出结合能力。在4例因转移性乳腺癌接受主要内分泌消融治疗且有有效反应的患者中，癌症的继发性转移灶在内分泌消融后很长时间仍显示出雌激素结合能力。内分泌消融使初始肿瘤完全或部分消退后再生长的肿瘤保留雌激素受体这一事实，似乎与激素操纵后乳腺癌复发的自主性经典概念相矛盾。
