Merville C, Charlet P, Zerr C, Bricard H
Département d'Anesthesie-Réanimation Chirurgicale, CHU Côte-de-Nacre, Caen.
Ann Fr Anesth Reanim. 1991;10(6):548-53. doi: 10.1016/s0750-7658(05)80293-x.
The efficiency of two intraoperative techniques of blood saving were compared prospectively. During a period of eight months, in 120 adults patients undergoing heart surgery with a cardiopulmonary bypass (CPB). They all had blood removed before the start of CPB for isovolaemic haemodilution. They were randomly assigned to two groups (n = 60 for each): for group A patients, blood was salvaged during surgery before the start of the CPB, during cardioplegia, and from the CPB circuit at the end of surgery, using a Cell Saver 1V (Haemonetics), and returned to the patient in theatre or in intensive care; in group B patients, blood in the CPB circuit at the end of surgery was ultrafiltered and returned to the patient at the same time as 0.8 mg.kg-1 protamine sulfate. The same anaesthetic protocol was used in all the patients (flunitrazepam, phenoperidine and pancuronium bromide). There was no significant difference between the two groups in the volume of blood removed at the start of surgery (9.12 +/- 2.01 ml.kg-1 (A) vs. 8.85.2.22 ml.kg-1 (B)), in the amounts of replacement fluid (Haemaccel, 4% albumin) given to maintain volaemia, and in postoperative blood loss Red cell count, haemoglobin level and haematocrit were higher in the Cell Saver group at the third postoperative hour and on the first postoperative day, whereas fibrinogen levels and platelet count were higher in the ultrafiltration group at the same times. A mean of 1.02 +/- 1.71 homologous blood units were given to group A and 1.45 +/- 1.71 in group B (not significant).(ABSTRACT TRUNCATED AT 250 WORDS)
前瞻性比较了两种术中血液保存技术的效率。在八个月的时间里,对120例接受体外循环心脏手术的成年患者进行了研究。在体外循环开始前,他们均进行了血液采集以进行等容血液稀释。患者被随机分为两组(每组n = 60):A组患者在手术期间、体外循环开始前、心脏停搏期间以及手术结束时从体外循环回路中使用Cell Saver 1V(Haemonetics)回收血液,并在手术室或重症监护室回输给患者;B组患者在手术结束时对体外循环回路中的血液进行超滤,并在给予0.8mg·kg-1硫酸鱼精蛋白的同时回输给患者。所有患者均采用相同的麻醉方案(氟硝西泮、苯哌啶和潘库溴铵)。两组在手术开始时采集的血液量(9.12±2.01ml·kg-1(A组)对8.85±2.22ml·kg-1(B组))、为维持血容量给予的替代液量(贺斯、4%白蛋白)以及术后失血量方面无显著差异。术后第三小时和术后第一天,Cell Saver组的红细胞计数、血红蛋白水平和血细胞比容较高,而超滤组在同一时间的纤维蛋白原水平和血小板计数较高。A组平均给予1.02±1.71个单位的同源血,B组为1.45±1.71个单位(无显著差异)。(摘要截断于250字)