Sawyer D C, Rech R H, Durham R A, Adams T, Richter M A, Striler E L
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
Am J Vet Res. 1991 Nov;52(11):1826-30.
Butorphanol (0.025, 0.05, 0.1, 0.2, 0.4, and 0.8 mg/kg of body weight, and placebo) was given SC to 8 healthy unmedicated dogs to determine its efficacy for visceral analgesia, using a colonic balloon for minimal threshold nociceptor stimulation. Degree of sedation; systolic, diastolic, and mean arterial pressure; and pulse rate were recorded. The highest 3 dosages, 0.2, 0.4, and 0.8 mg/kg, were found to be most effective, with 0.8 mg/kg the only dosage that was significantly different from control responses at the 45-minute interval. Duration of analgesia ranged from 23 to 53 minutes for all 6 dosages and dosing durations were not significantly different from one another. Blood pressures did not change, but pulse rate was significantly decreased by 0.8 mg of butorphanol/kg. We concluded that butorphanol is an effective visceral analgesic of relatively short duration in the dog.
将布托啡诺（0.025、0.05、0.1、0.2、0.4和0.8毫克/千克体重，以及安慰剂）皮下注射给8只未用药的健康犬，使用结肠气囊对最小阈值伤害感受器进行刺激，以确定其内脏镇痛效果。记录镇静程度、收缩压、舒张压和平均动脉压以及脉搏率。发现最高的3个剂量，即0.2、0.4和0.8毫克/千克，最为有效，其中0.8毫克/千克是在45分钟间隔时唯一与对照反应有显著差异的剂量。所有6个剂量的镇痛持续时间为23至53分钟，给药持续时间彼此之间无显著差异。血压未发生变化，但布托啡诺0.8毫克/千克可使脉搏率显著降低。我们得出结论，布托啡诺是犬体内一种起效相对较快、持续时间较短的有效内脏镇痛药。
