Kalpravidh M, Lumb W V, Wright M, Heath R B
Am J Vet Res. 1984 Feb;45(2):211-6.
The analgesic effects of butorphanol (0.05, 0.1, 0.2, and 0.4 mg/kg), pentazocine (2.2 mg/kg), and butorphanol vehicle (0.04 ml/kg) were observed in 6 horses. These horses were instrumented to measure response objectively to painful superficial and visceral stimuli. The tested drugs were given IV according to a Latin square design. After preinjection base-line measurements were made, the analgesic effects were observed at 15 and 30 minutes and then at 30-minute intervals until postinjection minute 240. Analgesic effects of butorphanol were dose-related, with durations between 15 and 90 minutes. Duration of analgesia after pentazocine (2.2 mg/kg) was given was between 15 and 30 minutes. When compared with pentazocine, the 0.4 mg/kg dose of butorphanol provided a more intense and longer period of analgesia. A butorphanol dose of 0.2 mg/kg IV appears optimal. On a dose-body weight basis, the potency of butorphanol was 10 to 17 times that of pentazocine. Behavioral side effects were noted with both agents and were dose-related.
在6匹马中观察了布托啡诺（0.05、0.1、0.2和0.4mg/kg）、喷他佐辛（2.2mg/kg）和布托啡诺溶媒（0.04ml/kg）的镇痛效果。这些马被安装仪器以客观测量对疼痛的体表和内脏刺激的反应。受试药物按照拉丁方设计静脉注射。在注射前进行基线测量后，于15分钟和30分钟时观察镇痛效果，然后每隔30分钟观察一次，直至注射后240分钟。布托啡诺的镇痛效果与剂量相关，持续时间在15至90分钟之间。给予喷他佐辛（2.2mg/kg）后的镇痛持续时间在15至30分钟之间。与喷他佐辛相比，0.4mg/kg剂量的布托啡诺产生的镇痛作用更强且持续时间更长。静脉注射0.2mg/kg剂量的布托啡诺似乎最为适宜。以剂量-体重为基础计算，布托啡诺的效力是喷他佐辛的10至17倍。两种药物均出现了行为学副作用，且与剂量相关。
