Torry D S, Faulk W P, McIntyre J A
Department of Pathology, Harvard Medical School, Boston, Massachusetts.
Am J Reprod Immunol. 1991 May;25(4):181-4. doi: 10.1111/j.1600-0897.1991.tb01091.x.
Successful reproduction in mammals requires the mother to immunologically accept genetically disparate tissues. Allotypic trophoblast antigens (TLX) are thought to be responsible for influencing maternal acceptance of the feto-placental graft, and faulty regulation of immunity to TLX antigens has been associated with recurrent pregnancy losses. In this report, rabbit antiidiotype (RAb2) was produced to a human TLX antibody (Ab1). This RAb2 detected TLX cross-reactive idiotypes (CRI) on antitrophoblast IgG from women with normal and abnormal pregnancies. These findings support an hypothesis that women respond immunologically to allotypic trophoblast antigens, and that idiotype-antiidiotype regulation of this response is characteristic of normal pregnancy.
哺乳动物成功繁殖需要母体在免疫上接受基因不同的组织。同种异型滋养层抗原（TLX）被认为是影响母体对胎儿 - 胎盘移植物接受度的原因，并且对TLX抗原免疫调节异常与复发性流产有关。在本报告中，制备了针对人TLX抗体（Ab1）的兔抗独特型抗体（RAb2）。该RAb2在正常和异常妊娠女性的抗滋养层IgG上检测到TLX交叉反应性独特型（CRI）。这些发现支持了这样一种假说，即女性对同种异型滋养层抗原会产生免疫反应，并且这种反应的独特型 - 抗独特型调节是正常妊娠的特征。
