Roumen G, Roussev M D, Vanderpuye O A, Wagenknecht D R, McIntyre J A
Center for Reproduction and Transplantation Immunology, Methodist Hospital for Indiana, Indianopolis 46202.
Acta Eur Fertil. 1991 May-Jun;22(3):181-7.
Maternal responses to allotypic TLX antigens are proposed as necessary in the immunological maintenance of human pregnancy. The TLX antigens are strategically and strongly expressed in semen and on the extraembryonic tissues which form the anatomical materno-fetal interfaces. Recent findings suggest that CD 46 proteins (a membrane cofactor which protects self tissues from autologous complement damage) in association with the activated complement component, C 3b produce a novel antigenic epitope recognized by both rabbit and human anti-TLX antisera. Control of TLX immunity involves an idiotype-antiidiotype network. We now report the development of rabbit antiidiotypes specific for cross-reactive idiotypes on human anti-TLX IgG antibodies. These antiidiotypes appear to recognize different TLX allotypes and will be useful for gaining additional insight into the immunogenetics of human reproduction.
母体对同种异型TLX抗原的反应被认为是人类妊娠免疫维持所必需的。TLX抗原在精液和形成母胎解剖界面的胚外组织中呈策略性且强烈表达。最近的研究结果表明，CD46蛋白（一种保护自身组织免受自体补体损伤的膜辅因子）与活化的补体成分C3b结合，产生一种新的抗原表位，兔和人抗TLX抗血清均可识别。TLX免疫的控制涉及独特型-抗独特型网络。我们现在报告针对人抗TLX IgG抗体上交叉反应独特型的兔抗独特型的研制情况。这些抗独特型似乎能识别不同的TLX同种异型，将有助于深入了解人类生殖的免疫遗传学。
