Scholz J, Roewer N, Troll U, Patten M, Schmitz W, Scholz H, Schulte am Esch J
Abteilung für Anästhesiologie, Universitäts-Krankenhaus Eppendorf, Hamburg.
Anasthesiol Intensivmed Notfallmed Schmerzther. 1991 Dec;26(8):450-3. doi: 10.1055/s-2007-1000614.
There are recent reports that inositol phosphate metabolism is involved in the development of malignant hyperthermia (MH). Consequently, we investigated the basal concentration of inositol phosphate products in skeletal and heart muscles of malignant hyperthermia-susceptible (MHS) and healthy control (MHN) swine. Different inositol phosphates were measured by high pressure liquid chromatography, including inositol trisphosphate, tetrakisphosphate, pentakisphosphate and hexakisphosphate. All inositol phosphate products measured had a higher concentration in MHS than MHN in skeletal (304-1330%) as well as heart muscles (134-440%). An activation of the inositol phosphate metabolism has been shown to mobilise intracellular calcium from the sarcoplasmic reticulum. It is therefore concluded that, firstly, besides involvement of the skeletal muscles a primary myocardial abnormality in MHS is possible; and secondly, the idea that the inositol phosphate metabolism could be involved in the development of MH is additionally supported.
最近有报道称肌醇磷酸代谢与恶性高热（MH）的发生发展有关。因此，我们研究了恶性高热易感（MHS）猪和健康对照（MHN）猪的骨骼肌和心肌中肌醇磷酸产物的基础浓度。通过高压液相色谱法测定了不同的肌醇磷酸，包括肌醇三磷酸、四磷酸、五磷酸和六磷酸。在骨骼肌（304 - 1330%）和心肌（134 - 440%）中，所有测定的肌醇磷酸产物在MHS中的浓度均高于MHN。已证明肌醇磷酸代谢的激活可从肌浆网中动员细胞内钙。因此得出结论：首先，除了骨骼肌受累外，MHS中可能存在原发性心肌异常；其次，这进一步支持了肌醇磷酸代谢可能参与MH发生发展的观点。
