Yamashita M, Yasuda H, Sonobe M, Hisanaga T, Shigeta Y
Third Department of Medicine, Shiga University of Medical Science.
Rinsho Shinkeigaku. 1991 Jul;31(7):734-7.
A case of spinal cord sarcoidosis was reported with special reference to MRI findings. A 15-year-old man was admitted to our hospital because of gait disturbance for last six months. Neurological examination on admission showed spastic paraparesis and posterior column signs. MRI of the cervical spinal cord revealed diffuse swelling and low intensity signal in T1-weighted sequences, diffuse high intensity signal in T2-weighted, and multiple micro-nodular lesion in Gd-DTPA enhanced T1-weighted. At first multiple sclerosis was suspected, although the data of cerebrospinal fluid was not suggestive. Four weeks after admission general fatigue, fever, cough, and headache appeared and the neurological symptoms got worse. Chest film and CT revealed diffuse small nodular shadows in the lung field. Abdominal ultrasonography and CT showed hepatosplenomegaly. The general condition became worse in spite of antibiotic and antituberculotic drug therapy, but remitted spontaneously in four weeks. MRI findings also exacerbated and improved during the same period, being compatible with neurological manifestations. The diagnosis of sarcoidosis was made by transbronchial lung biopsy which revealed sarcoid granuloma. Multiple small nodules on Gd-DTPA enhanced T1-weighted MRI had not been reported in patient with spinal cord sarcoidosis.
报告了一例脊髓结节病,并特别提及MRI表现。一名15岁男性因过去六个月步态障碍入院。入院时神经系统检查显示痉挛性截瘫和后索体征。颈椎脊髓MRI显示在T1加权序列中弥漫性肿胀和低强度信号,在T2加权中弥漫性高强度信号,以及在钆喷酸葡胺增强T1加权中有多个微小结节病变。最初怀疑是多发性硬化症,尽管脑脊液数据并不支持。入院四周后出现全身乏力、发热、咳嗽和头痛,神经症状加重。胸部X线片和CT显示肺野弥漫性小结节阴影。腹部超声和CT显示肝脾肿大。尽管使用了抗生素和抗结核药物治疗,一般情况仍恶化,但四周后自发缓解。在此期间MRI表现也加重并改善,与神经表现相符。通过经支气管肺活检做出结节病的诊断,显示结节病肉芽肿。脊髓结节病患者在钆喷酸葡胺增强T1加权MRI上出现多个小结节尚未见报道。