Terai S, Yoshida Y, Yamaguchi T, Hasuo K
Department of Internal Medicine, Chidoribashi Hospital.
Rinsho Shinkeigaku. 1990 Apr;30(4):407-12.
A 70-year-old man, with slowly progressive gait disturbance, numbness in his lower limbs and dysuria, was admitted to our hospital in July, 1988. Neurological examination revealed flaccid paraparesis, hyperesthesia below the level of Th-10 combined with the disturbance of pain and temperature sensations below the level of Th-11, and neurogenic bladder. Midsagittal Tl-weighed image of MRI did not reveal any abnormal finding except for a mild enlargement of the conus medullaris. With Gadolinium (Gd)-DTPA injection, however, the spinal cord was diffusely enhanced below the level of the 9th thoracic spine. This enhancement effect was particularly remarkable at the periphery of the spinal image showing several high intensity spots in the posterior aspect of the spinal cord, which was thought to be incompatible with the spinal cord neoplasm. The angiographic examination of the selective Th-7 intercostal artery on the left showed vascular malformation lying adjacent to the 7th intervertebral foramen with markedly dilated tortuous spinal veins going upwards and downwards, which was compatible with spinal dural arteriovenous malformation (AVM). After the artificial embolization, draining veins as well the nidus of AVM had completely disappeared on angiogram. There was an improvement on his neurological findings and Gd-DTPA enhancement had been diminished on MRI. It was suggested that Gd-DTPA enhancement on MRI was due to the dilated and remarkably congestive spinal veins, and that both the elevated venous pressure and reduction of intramedullary arteriovenous pressure gradient were the cause of the development of clinical symptoms.
一名70岁男性,因步态逐渐缓慢不稳、下肢麻木及排尿困难,于1988年7月入院。神经系统检查发现弛缓性截瘫、T10水平以下感觉过敏,伴有T11水平以下痛温觉障碍及神经源性膀胱。MRI矢状位T1加权像除脊髓圆锥轻度增大外未发现任何异常。然而,注射钆(Gd)-二乙三胺五乙酸(DTPA)后,第9胸椎水平以下脊髓弥漫性强化。这种强化效应在脊髓影像周边尤为显著,在脊髓后侧显示出几个高强度点,这被认为与脊髓肿瘤不相符。选择性左第7肋间动脉血管造影检查显示,第7椎间孔附近存在血管畸形,脊髓静脉明显扩张迂曲,上下走行,符合脊髓硬脊膜动静脉畸形(AVM)。人工栓塞后,血管造影显示引流静脉及AVM病灶完全消失。其神经学表现有所改善,MRI上Gd-DTPA强化减弱。提示MRI上Gd-DTPA强化是由于脊髓静脉扩张和明显充血,静脉压升高和髓内动静脉压力梯度降低是临床症状出现的原因。