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[脊髓结节病——钆增强磁共振成像的诊断价值]

[Spinal cord sarcoidosis--diagnostic value of Gd-enhanced MRI].

作者信息

Kameyama T, Ando T, Saito Y, Takahashi A, Yamada H

机构信息

Department of Neurology, Nagoya University School of Medicine.

出版信息

Rinsho Shinkeigaku. 1992 Jun;32(6):631-6.

PMID:1424344
Abstract

A 50-year-old man was admitted because of slowly progressive myelopathy for the last ten months without a correct diagnosis. The CSF showed mild pleocytosis (predominantly mononuclear cells) together with elevated protein content. MRI findings after administration of Gd-DTPA were characteristic: diffuse swelling of the lower cervical and upper thoracic cord, multiple patchy enhanced areas in the cord parenchyma adjacent to meninges, and linear meningeal enhancement. Based on these observations, a scalene node biopsy was performed, yielding a pathological diagnosis of sarcoidosis. The clinical neurological signs as well as the abnormal MRI findings of myelopathy were considerably improved after prednisolone therapy. An early diagnosis of spinal cord involvement in sarcoidosis should be established, because it is treatable in the earlier stage. Mild inflammatory evidence in CSF and Gd-enhanced MRI findings may be the cardinal clues to the diagnosis.

摘要

一名50岁男性因过去十个月来缓慢进展的脊髓病入院,此前未得到正确诊断。脑脊液显示轻度细胞增多(主要为单核细胞),同时蛋白含量升高。静脉注射钆喷酸葡胺(Gd-DTPA)后的MRI表现具有特征性:下颈段和上胸段脊髓弥漫性肿胀,脊髓实质内靠近脑膜处有多个斑片状强化区域,以及脑膜线状强化。基于这些观察结果,进行了斜角肌淋巴结活检,病理诊断为结节病。泼尼松龙治疗后,临床神经体征以及脊髓病的异常MRI表现有了显著改善。应尽早诊断结节病累及脊髓,因为早期可治疗。脑脊液中的轻度炎症证据和Gd增强MRI表现可能是诊断的主要线索。

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