Kamaluddin M, Misbahuddin M
Deptt. of Pharmacology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka.
Bangladesh Med Res Counc Bull. 2006 Dec;32(3):87-91.
To examine the effect of zinc in the removal of accumulated arsenic from different tissues (liver, kidneys, spleen and lungs), rats were initially allowed to drink high concentration (400 microg/kg/day) of arsenic for two months followed by a period of cessation (one month). Administration of zinc (2 mg/kg/day) during the third month in arsenic-treated and non-treated groups were compared. In arsenic-treated rats, the mean (+/- SD) amounts of total arsenic in liver, kidneys, spleen and lungs were 12.3 +/- 0.7, 20.5 +/- 1.0, 31.4 +/- 1.0 and 25.6 +/- 1.1 microg/g of tissues respectively. Administration of zinc to arsenic-treated rats reduced the arsenic concentrations of those tissues to 7.8, 10.7, 23.0 and 14.0 microg/g of tissues. This in vivo study suggests that zinc removes the accumulated arsenic from different tissues significantly (p < 0.001).
为了研究锌对从不同组织（肝脏、肾脏、脾脏和肺）中去除蓄积砷的作用，首先让大鼠饮用高浓度（400微克/千克/天）的砷两个月，随后停止饮用一段时间（一个月）。比较了在第三个月时砷处理组和未处理组给予锌（2毫克/千克/天）的情况。在砷处理的大鼠中，肝脏、肾脏、脾脏和肺中总砷的平均（±标准差）含量分别为12.3±0.7、20.5±1.0、31.4±1.0和25.6±1.1微克/克组织。给砷处理的大鼠施用锌后，这些组织中的砷浓度降至7.8、10.7、23.0和14.0微克/克组织。这项体内研究表明，锌能显著地从不同组织中去除蓄积的砷（p<0.001）。
