Yan Eric, Durazo Francisco, Tong Myron, Hong Kurt
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Nutr Rev. 2007 Aug;65(8 Pt 1):376-84. doi: 10.1301/nr.2007.aug.376-384.
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver diseases in the absence of significant alcohol consumption, and its incidence is paralleling the increasing numbers of overweight and obese individuals worldwide. This review discusses the pathogenesis of NAFLD, including the roles potentially played by specific adipokines, such as TNF-alpha, leptin, and adiponectin. Clinical features, diagnosis, and potential methods of management are also addressed to assist practitioners with the management of this growing population of patients.
非酒精性脂肪性肝病（NAFLD）涵盖了一系列在无大量饮酒情况下出现的肝脏疾病，其发病率与全球超重和肥胖个体数量的增加同步。本综述讨论了NAFLD的发病机制，包括特定脂肪因子（如肿瘤坏死因子-α、瘦素和脂联素）可能发挥的作用。还阐述了临床特征、诊断及潜在的管理方法，以帮助从业者管理这一不断增长的患者群体。
