Wadood Noreen, Nisar Muhammad, Rashid Abdul, Wadood Abdul, Khan Ayub
Department of Biochemistry, Kabir Medical College, Peshawar.
J Ayub Med Coll Abbottabad. 2007 Jan-Mar;19(1):32-8.
The present study was planned to observe the hypoglycaemic effect of the 'Compound recipe' a combination of traditional medicinal plants in normal and alloxan induced diabetes mellitus. This study was performed to study the possible role of indigenous medicinal plants in the regeneration of pancreatic beta-cells and in treatment of insulin dependent diabetes mellitus.
The 'Compound recipe' was administered daily in doses of 400-mg/kg body weight to normal and alloxan induced diabetic rabbits for a period of 4 months. The blood glucose and serum insulin levels were estimated before and 1, 2, 3 and 4 months after the administration of the extract.
The extract exerted a significant (p<0.05) hypoglycemic effect in alloxan diabetic rabbits. The hypoglycemic effect was not significant (p>0.05) in normal rabbits. The extract exerted a significant (p<0.05) increase in insulin levels in alloxan diabetic rabbits. The effect on the insulin levels was not significant (p>0.05) in normal rabbits. The doses used did not show acute toxicity or result in behavioral changes.
From this study it may be concluded that the Compound recipe causes an increase in serum insulin levels in alloxan induced diabetic rabbits possibly due to regeneration of pancreatic beta cells.
本研究旨在观察“复方配方”（一种传统药用植物组合）对正常及四氧嘧啶诱导的糖尿病的降血糖作用。本研究旨在探讨本土药用植物在胰腺β细胞再生及胰岛素依赖型糖尿病治疗中的可能作用。
将“复方配方”以400毫克/千克体重的剂量每日给予正常及四氧嘧啶诱导的糖尿病兔，持续4个月。在给予提取物前及给药后1、2、3和4个月时测定血糖和血清胰岛素水平。
该提取物对四氧嘧啶糖尿病兔有显著（p<0.05）的降血糖作用。对正常兔的降血糖作用不显著（p>0.05）。该提取物使四氧嘧啶糖尿病兔的胰岛素水平显著（p<0.05）升高。对正常兔胰岛素水平的影响不显著（p>0.05）。所用剂量未显示急性毒性或导致行为改变。
从本研究可以得出结论，复方配方可能通过胰腺β细胞再生导致四氧嘧啶诱导的糖尿病兔血清胰岛素水平升高。
