Wang Yizhong, Vera Claudia I Rivera, Lin Qing
Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Org Lett. 2007 Oct 11;9(21):4155-8. doi: 10.1021/ol7017328. Epub 2007 Sep 15.
A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regioselectivity, and yield.
已成功开发出一种温和的、光活化的1,3 - 偶极环加成方法用于合成多取代吡唑啉。该方法包括使用302 nm的手持式紫外灯原位生成活性腈亚胺偶极子，随后与多种1,3 - 偶极亲双烯体自发进行环加成反应，具有出色的溶剂兼容性、官能团耐受性、区域选择性和产率。
