Sun Jian, Chan Chi-Chiu, Dong Xin-Yong, Shum Ping
Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, Singapore 637457.
J Biomed Opt. 2007 Jul-Aug;12(4):044022. doi: 10.1117/1.2753439.
The use of photonic bandgap fibers (PBGF) for biomedical sensing has been demonstrated. The demonstrated PBGF has a blue wavelength shift of 280 nm in the falling photonic bandgap edge (PBE) when the ambient refractive indices inside the holey region change from 1.333 to 1.39, which agrees well with the analytical prediction. Combining this with the knowledge of immobilization techniques and biorecognition elements could open up a new class of PBGF-based label-free biosensors. A sensitivity on the order of 0.1 nmol/L could be achieved by consuming less than 1 microL of sample.
已证明光子带隙光纤（PBGF）可用于生物医学传感。当多孔区域内的环境折射率从1.333变为1.39时，所展示的PBGF在下降的光子带隙边缘（PBE）处有280 nm的蓝色波长偏移，这与分析预测结果吻合良好。将此与固定化技术和生物识别元件的知识相结合，可能会开创一类基于PBGF的无标记生物传感器。通过消耗少于1微升的样品，可实现约0.1 nmol/L的灵敏度。
