Obermann Mark, Katsarava Zaza
University of Duisburg-Essen, Department of Neurology, Hufelandstr. 55, 45122 Essen, Germany.
Expert Rev Neurother. 2007 Sep;7(9):1145-55. doi: 10.1586/14737175.7.9.1145.
Medication-overuse headache (MOH) has developed into the third most common type of headache after tension-type headache and migraine. The prevalence reaches approximately 1% of the world's population and shows an increasing trend. Many important studies on MOH have been published in the last year, some of which investigated the pathophysiology of headache chronicity, with others focusing on the evaluation of risk factors. The International Headache Society revised its classification criteria on MOH. Several large population-based longitudinal studies clearly demonstrated that overuse of any kind of acute headache medication is the main risk factor leading to the development of chronic headache. Management of MOH remains difficult; the only effective treatment concept is consequent withdrawal therapy.
药物过量使用性头痛（MOH）已成为继紧张型头痛和偏头痛之后的第三大常见头痛类型。其患病率约占世界人口的1%，且呈上升趋势。去年发表了许多关于MOH的重要研究，其中一些研究调查了头痛慢性化的病理生理学，另一些则侧重于危险因素的评估。国际头痛协会修订了其关于MOH的分类标准。几项基于大规模人群的纵向研究清楚地表明，过度使用任何一种急性头痛药物是导致慢性头痛发生的主要危险因素。MOH的治疗仍然困难；唯一有效的治疗理念是持续的撤药疗法。
