Fondazione IRCCS Istituto Neurologico C. Besta, Via Celoria 11, 20133, Milan, Italy.
Neurol Sci. 2010 Jun;31 Suppl 1:S83-5. doi: 10.1007/s10072-010-0294-5.
Patients with chronic migraine are difficult to treat and often analgesic overusers. In this article attention is focused on aspects considered important for producing a definition of refractory in relation to this headache form. I propose that a "chronic migraine" patient should be considered "refractory" to pharmacological prophylaxis when adequate trials of preventive therapies at adequate doses have failed to reduce headache frequency and improve headache-related disability and, in patients with medication overuse, also failed to reduce the consumption of symptomatic drugs.
慢性偏头痛患者的治疗较为困难，且往往存在过度使用镇痛药的情况。本文主要关注与这种头痛类型相关的难治性定义的重要方面。我建议，当充分剂量的预防治疗试验未能降低头痛频率和改善与头痛相关的残疾，并且在药物滥用患者中也未能减少对症药物的使用时，应将“慢性偏头痛”患者视为对药物预防治疗难治。
